Toplam 517 içerik listeleniyor
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Cells are crawling all over our bodies, but how?
For better and for worse, human health depends on a cell's motility –– the ability to crawl from place to place. In every human body, millions of cells –are crawling around doing mostly good deeds ––– though if any of those crawlers are cancerous, watch out.
https://www.biyologlar.com/cells-are-crawling-all-over-our-bodies-but-how -
Function of mysterious RNAs may often lie in their genes
Scientists from Penn Medicine and other institutions unlock a mystery about 'long non-coding RNAs'. A new genetic clue discovered by a team co-led by a researcher at the Perelman School of Medicine at the University of Pennsylvania is shedding light on the functions of the mysterious "long non-coding RNAs" (lncRNAs). These molecules are transcribed from genes and are often abundant in cells, yet they do not code for proteins. Their functions have been almost entirely unknown--and in recent...
https://www.biyologlar.com/function-of-mysterious-rnas-may-often-lie-in-their-genes-haber-8132 -
First computer program developed to detect DNA mutations in single cancer cells
Researchers at The University of Texas MD Anderson Cancer Center have announced a new method for detecting DNA mutations in a single cancer cell versus current technology that analyzes millions of cells which they believe could have important applications for cancer diagnosis and treatment. The results are published in the April 18 online issue of Nature Methods.
https://www.biyologlar.com/first-computer-program-developed-to-detect-dna-mutations-in-single-cancer-cells-haber-8711 -
Scientists find brain cells that know which end is up
People are intuitive physicists, knowing from birth how objects under the influence of gravity are likely to fall, topple or roll. In a new study, scientists have found the brain cells apparently responsible for this innate wisdom.
https://www.biyologlar.com/scientists-find-brain-cells-that-know-which-end-is-up-haber-8720 -
Building a CRISPR rainbow
CRISPRainbow, a new technology using CRISPR/Cas9 developed by scientists at UMass Medical School, allows researchers to tag and track up to seven different genomic locations in live cells. This labeling system, details of which were published in Nature Biotechnology, will be an invaluable tool for studying the structure of the genome in real time.
https://www.biyologlar.com/building-a-crispr-rainbow-haber-8722 -
Gene therapy clips out heart failure causing gene mutations
This image shows the heart failure gene editing process. Gene therapy can clip out genetic material linked to heart failure and replace it with the normal gene in human cardiac cells, according to a study led by researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai. The study is published in the April 29 edition of Nature Communications.
https://www.biyologlar.com/gene-therapy-clips-out-heart-failure-causing-gene-mutations-haber-8764 -
Ekrana bakma süresi uyku düzenini bozabilir?
Soldan sağa: Salk Enstitüsünden Ludovic Mure ve Satchin Panda belli retinal hücrelerin yapay aydınlatmaya nasıl yanıt verdiğini ortaya çıkardı. Credit: Salk Institute
https://www.biyologlar.com/ekrana-bakma-suresi-uyku-duzenini-bozabilir -
Ekrana bakma süresi uyku düzenini bozabilir?
Soldan sağa: Salk Enstitüsünden Ludovic Mure ve Satchin Panda belli retinal hücrelerin yapay aydınlatmaya nasıl yanıt verdiğini ortaya çıkardı. Credit: Salk Institute
https://www.biyologlar.com/ekrana-bakma-suresi-uyku-duzenini-bozabilir -
Ekrana bakma süresi uyku düzenini bozabilir?
Soldan sağa: Salk Enstitüsünden Ludovic Mure ve Satchin Panda belli retinal hücrelerin yapay aydınlatmaya nasıl yanıt verdiğini ortaya çıkardı. Credit: Salk Institute
https://www.biyologlar.com/ekrana-bakma-suresi-uyku-duzenini-bozabilir -
Mitokondrial MTND1 Gen Mutasyonu İle İlişkili Lohn/Melas Örtüşme Sendromu
Mitokondrial MTND1 genindeki patojenik nokta mutasyonları daha önce iki farklı klinik fenotiple ilişkili olarak tanımlanmıştır –LHON ve MELAS -.Burada MTND1 geninde ,hem LHON hem de MELAS’ın klinik özelliklerini içeren bir örtüşme sendromu ile ilişkili ilk heteroplazmik mitokondrial DNA nokta mutasyonunu rapor ediyoruz.Kas histokimyasında ince mitokondrial anormallikler ortaya çıkmışken biyokimya analizinde izole bir kompleks I eksikliği...
https://www.biyologlar.com/mitokondrial-mtnd1-gen-mutasyonu-ile-iliskili-lohnmelas-ortusme-sendromu -
Mitokondrial MTND1 Gen Mutasyonu İle İlişkili Lohn/Melas Örtüşme Sendromu
Mitokondrial MTND1 genindeki patojenik nokta mutasyonları daha önce iki farklı klinik fenotiple ilişkili olarak tanımlanmıştır –LHON ve MELAS -.Burada MTND1 geninde ,hem LHON hem de MELAS’ın klinik özelliklerini içeren bir örtüşme sendromu ile ilişkili ilk heteroplazmik mitokondrial DNA nokta mutasyonunu rapor ediyoruz.Kas histokimyasında ince mitokondrial anormallikler ortaya çıkmışken biyokimya analizinde izole bir kompleks I eksikliği...
https://www.biyologlar.com/mitokondrial-mtnd1-gen-mutasyonu-ile-iliskili-lohnmelas-ortusme-sendromu -
CAR T-Hücrelerinin Güvenliğini Arttırmak için Yeni Fikirler
Romatoid artritin tedavisi için onaylanan ilaçlar, immünoterapiden kaynaklanan ciddi yan etkilerden sorumlu moleküller olan sitokinleri bloke ediyor ve farelerde semptomları azaltıyor.
https://www.biyologlar.com/car-t-hucrelerinin-guvenligini-arttirmak-icin-yeni-fikirler -
CAR T-Hücrelerinin Güvenliğini Arttırmak için Yeni Fikirler
Romatoid artritin tedavisi için onaylanan ilaçlar, immünoterapiden kaynaklanan ciddi yan etkilerden sorumlu moleküller olan sitokinleri bloke ediyor ve farelerde semptomları azaltıyor.
https://www.biyologlar.com/car-t-hucrelerinin-guvenligini-arttirmak-icin-yeni-fikirler -
Tedavide ‘’Kök Hücre’’
Vücudumuzda yaşlanan ve ölen hücrelerin yerlerine yenileri oluşturulmaktadır. Bununla birlikte, yabancı antijenlerle savaşmak için vücut özel savunma hücreleri de üretmektedir. Gözümüzdeki hücreler görme, pankreastaki hücreler salgı, akciğerdeki hücreler solunum için farklılaşmaktadır.
https://www.biyologlar.com/tedavide-kok-hucre -
Tedavide ‘’Kök Hücre’’
Vücudumuzda yaşlanan ve ölen hücrelerin yerlerine yenileri oluşturulmaktadır. Bununla birlikte, yabancı antijenlerle savaşmak için vücut özel savunma hücreleri de üretmektedir. Gözümüzdeki hücreler görme, pankreastaki hücreler salgı, akciğerdeki hücreler solunum için farklılaşmaktadır.
https://www.biyologlar.com/tedavide-kok-hucre -
Öğrenme ve Hafızaya Bağışıklık Hücrelerinin Etkisi Nasıldır?
Tiroyaone Brombacher adlı araştırmacı, suyla dolu bir metre genişliğindeki bir küvetin etrafında yüzen bir albino farenin videosunu izliyordu. Bu farenin interlökin 13 (IL-13) adlı bağışıklık proteini yoktu.
https://www.biyologlar.com/ogrenme-ve-hafizaya-bagisiklik-hucrelerinin-etkisi-nasildir -
Öğrenme ve Hafızaya Bağışıklık Hücrelerinin Etkisi Nasıldır?
Tiroyaone Brombacher adlı araştırmacı, suyla dolu bir metre genişliğindeki bir küvetin etrafında yüzen bir albino farenin videosunu izliyordu. Bu farenin interlökin 13 (IL-13) adlı bağışıklık proteini yoktu.
https://www.biyologlar.com/ogrenme-ve-hafizaya-bagisiklik-hucrelerinin-etkisi-nasildir -
Cell stress inflames the gut
Over 3.5 million people in Europe and the US suffer from Crohn's disease or ulcerative colitis – the two most common forms of IBD. Chronic bowel inflammation is caused by an overreaction of the immune system to the bacteria which naturally occur in the gut. "This overreaction can come about if, for example, the anti-stress mechanism in the cells of the intestinal mucosa does not function correctly," explains Prof. Dirk Haller of the TUM Chair of Nutrition and Immunology. What Prof. Haller is...
https://www.biyologlar.com/cell-stress-inflames-the-gut -
Highly efficient CRISPR knock-in in mouse
Genome editing using CRISPR/Cas system has enabled direct modification of the mouse genome in fertilized mouse eggs, leading to rapid, convenient, and efficient one-step production of knockout mice without embryonic stem cells. In contrast to the ease of targeted gene deletion, the complementary application, called targeted gene cassette insertion or knock-in, in fertilized mouse eggs by CRISPR/Cas mediated genome editing still remains a tough challenge. Professor Kohichi Tanaka and Dr. Tomomi...
https://www.biyologlar.com/highly-efficient-crispr-knock-in-in-mouse -
Stem cells + nanofibers = Promising nerve research
Every week in his clinic at the University of Michigan, neurologist Joseph Corey, M.D., Ph.D., treats patients whose nerves are dying or shrinking due to disease or injury.
https://www.biyologlar.com/stem-cells-nanofibers-promising-nerve-research -
KÖK HÜCRELERE BAKIŞ:TANIMLAR, KAVRAMLAR ve SINIFLANDIRMALAR
İki binli yıllarla beraber kök hücrelerin rejeneratif tıp (yenileyici tıp) alanındaki öneminin giderek arttığını ve tıbbın geleceğini şekillendirme potansiyelini gözlemlemekteyiz.
https://www.biyologlar.com/kok-hucrelere-bakistanimlar-kavramlar-ve-siniflandirmalar -
Kanserle hayatta kalma konusundaki yeni atlas, yeni tedavilerin bulunmasını sağlayabilir.
Yeni atlas, bazı hastaların neden bu hastalıkla diğerlerine göre daha uzun yaşadığını açıklamaya yardımcı olabilir. Photo: Shutterstock
https://www.biyologlar.com/kanserle-hayatta-kalma-konusundaki-yeni-atlas-yeni-tedavilerin-bulunmasini-saglayabilir- -
Kanserle hayatta kalma konusundaki yeni atlas, yeni tedavilerin bulunmasını sağlayabilir.
Yeni atlas, bazı hastaların neden bu hastalıkla diğerlerine göre daha uzun yaşadığını açıklamaya yardımcı olabilir. Photo: Shutterstock
https://www.biyologlar.com/kanserle-hayatta-kalma-konusundaki-yeni-atlas-yeni-tedavilerin-bulunmasini-saglayabilir- -
B hücreleri, T hücrelerini beyne yönlendirir.
Multipl sklerozlu hastaların beyin dokusuna kendiliğinden giden T hücreleri, antijenle deneyimlenen B hücreleri tarafından yönlendirilir.
https://www.biyologlar.com/b-hucreleri-t-hucrelerini-beyne-yonlendirir- -
B hücreleri, T hücrelerini beyne yönlendirir.
Multipl sklerozlu hastaların beyin dokusuna kendiliğinden giden T hücreleri, antijenle deneyimlenen B hücreleri tarafından yönlendirilir.
https://www.biyologlar.com/b-hucreleri-t-hucrelerini-beyne-yonlendirir- -
Pancreas stem cell discovery may lead to new diabetes treatments
Stem cells in the adult pancreas have been identified that can be turned into insulin producing cells, a finding that means people with type 1 diabetes might one day be able to regenerate their own insulin-producing cells. The discovery was made by scientists from the Walter and Eliza Hall Institute and provides further evidence that stem cells don't only occur in the embryo. The ability to produce the hormone insulin is crucial for controlling blood sugar (glucose) levels. In people with...
https://www.biyologlar.com/pancreas-stem-cell-discovery-may-lead-to-new-diabetes-treatments -
GENETİK KOPYALAMA
İşçilerin tulumları beyazdı; ellerinde soğuk, kadavra rengi kauçuk eldivenler vardı. Işık donuktu, ölüydü: Bir hayalet sanki!.. Yalnız mikroskopların sarı borularından zengin ve canlı bir öz akıyor, bir baştan bir başa uzanan çalışma masalarının üzerinde tatlı çizgiler yaratarak, parlatılmış tüpler boyunca tereyağ gibi yayılıyordu. "Bu da" dedi Müdür kapıyı açarak, "döllenme odası işte..." Doğal olarak, ilkin döllenmenin cerrahlığa dayanan...
https://www.biyologlar.com/genetik-kopyalama -
New discovery in living cell signaling
A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant to therapy. An international collaboration of researchers, led by scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley, have unlocked the secret behind the activation of the...
https://www.biyologlar.com/new-discovery-in-living-cell-signaling -
Magnetic nanoparticles could be key to effective immunotherapy
In recent years, researchers have hotly pursued immunotherapy, a promising form of treatment that relies on harnessing and training the body's own immune system to better fight cancer and infection. Now, results of a study led by Johns Hopkins investigators suggests that a device composed of a magnetic column paired with custom-made magnetic nanoparticles may hold a key to bringing immunotherapy into widespread and successful clinical use. A summary of the research, conducted in mouse and human...
https://www.biyologlar.com/magnetic-nanoparticles-could-be-key-to-effective-immunotherapy -
Stem-cell approach shows promise for Duchenne muscular dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD. Their findings appear in the journal Stem Cells Translational Medicine. Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without...
https://www.biyologlar.com/stem-cell-approach-shows-promise-for-duchenne-muscular-dystrophy -
Blocking cells' movement to stop the spread of cancer
Insights into how cells move through the body could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours, according to new UCL research. Scientists discovered that cells can change into an invasive, liquid-like state to readily navigate the narrow channels in our body. This transformation is triggered by chemical signals, which could be blocked in order to stop cancer cells from spreading. Most cancer deaths are not due to primary tumours, but to...
https://www.biyologlar.com/blocking-cells-movement-to-stop-the-spread-of-cancer -
New resource makes gene-editing technology even more user friendly
Researchers at Harvard University and the University of California, San Diego, have developed a new user-friendly resource to accompany the powerful gene editing tool called CRISPR/Cas9, which has been widely adopted to make precise, targeted changes in DNA. This breakthrough has the potential to facilitate new discoveries in gene therapies and basic genetics research. The research was published in the July 13 issue of Nature Methods. The study describes an approach to simplify a laborious...
https://www.biyologlar.com/new-resource-makes-gene-editing-technology-even-more-user-friendly -
Stem-cell-based strategy boosts immune system in mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. The researchers showed that, in mice, the tissue can be used to foster the development of white blood cells the body needs to mount healthy immune responses and to prevent harmful autoimmune reactions. The scientists who developed the thymus cells — which caused the proliferation and maturation of functioning immune cells...
https://www.biyologlar.com/stem-cell-based-strategy-boosts-immune-system-in-mice -
Simple technology makes CRISPR gene editing cheaper
University of California, Berkeley, researchers have discovered a much cheaper and easier way to target a hot new gene editing tool, CRISPR-Cas9, to cut or label DNA. The CRISPR-Cas9 technique, invented three years ago at UC Berkeley, has taken genomics by storm, with its ability to latch on to a very specific sequence of DNA and cut it, inactivating genes with ease. This has great promise for targeted gene therapy to cure genetic diseases, and for discovering the causes of disease. The...
https://www.biyologlar.com/simple-technology-makes-crispr-gene-editing-cheaper -
Stem cell breakthrough could set up future transplant therapies
A new method for creating stem cells for the human liver and pancreas, which could enable both cell types to be grown in sufficient quantities for clinical use, has been developed by scientists. Using the technique, researchers have for the first time been able to grow a pure, self-renewing population of stem cells specific to the human foregut, the upper section of the human digestive system. These so-called "Foregut stem cells" could then be developed further to produce liver or pancreatic...
https://www.biyologlar.com/stem-cell-breakthrough-could-set-up-future-transplant-therapies -
Tam Kan Sayımı (KISALTMALARI )
Tam Kan Sayımı (Hemogram) -RBC: Red Blood Cells (Kırmızı kan hücrelerinin –eritrosit- sayısı)Bunlar oksijen taşıyan hücrelerdir. Ağır egzersiz ve yüksek rakımda sayıları artarken düşük olması kansızlık (anemi) veya kan kaybını gösterir. Ayrıca hemolize neden olan bazı ilaçlar da eritrosit sayısını azaltabilir.-HGB: Hemoglobin (Hb)Kandaki toplam hemoglobin miktarını gösterir. Anemi, kan kaybı, polistemi (eritrosit sayısının normalden fazla olması) v.b....
https://www.biyologlar.com/tam-kan-sayimi-kisaltmalari- -
Stanford researchers genetically engineer yeast to produce opioids
For thousands of years, people have used yeast to ferment wine, brew beer and leaven bread. Now researchers at Stanford have genetically engineered yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of plant-based medicines. Writing today in Science, the Stanford engineers describe how they reprogrammed the genetic machinery of baker's yeast so that these fast-growing cells could convert sugar into...
https://www.biyologlar.com/stanford-researchers-genetically-engineer-yeast-to-produce-opioids -
New stem cells go back further
One of the obstacles to employing human embryonic stem cells for medical use lies in their very promise: They are born to rapidly differentiate into other cell types.
https://www.biyologlar.com/new-stem-cells-go-back-further -
Enzyme controlling metastasis of breast cancer identified
Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide. An estimated 40,000 women in America will die of breast cancer in 2014, according to the American Cancer Society. "The take-home message of the study is that we have found a way to target breast cancer metastasis through a pathway...
https://www.biyologlar.com/enzyme-controlling-metastasis-of-breast-cancer-identified -
Stem cells from teeth can make brain-like cells
University of Adelaide researchers have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could one day be used in the brain as a therapy for stroke.
https://www.biyologlar.com/stem-cells-from-teeth-can-make-brain-like-cells -
Scientists discover an on-off switch for aging cells
Scientists at the Salk Institute have discovered an on-and-off "switch" in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age. In our bodies, newly divided cells constantly replenish lungs, skin, liver and other organs. However, most human cells cannot divide indefinitely–with each division, a cellular timekeeper at the ends of chromosomes shortens. When...
https://www.biyologlar.com/scientists-discover-an-on-off-switch-for-aging-cells -
Researchers use human stem cells to create light-sensitive retina in a dish
Using a type of human stem cell, Johns Hopkins researchers say they have created a three-dimensional complement of human retinal tissue in the laboratory, which notably includes functioning photoreceptor cells capable of responding to light, the first step in the process of converting it into visual images.
https://www.biyologlar.com/researchers-use-human-stem-cells-to-create-light-sensitive-retina-in-a-dish -
Genome-wide search reveals new genes involved in long-term memory
A new study has identified genes involved in long-term memory in the worm as part of research aimed at finding ways to retain cognitive abilities during aging. The study, which was published in the journal Neuron, identified more than 750 genes involved in long-term memory, including many that had not been found previously and that could serve as targets for future research, said senior author Coleen Murphy, an associate professor of molecular biology and the Lewis-Sigler Institute for...
https://www.biyologlar.com/genome-wide-search-reveals-new-genes-involved-in-long-term-memory -
New method to grow zebrafish embryonic stem cells can regenerate whole fish
Zebrafish, a model organism that plays an important role in biological research and the discovery and development of new drugs and cell-based therapies, can form embryonic stem cells (ESCs).
https://www.biyologlar.com/new-method-to-grow-zebrafish-embryonic-stem-cells-can-regenerate-whole-fish -
The Role of Insulin in the Human Body
Developed and produced by http://www.MechanismsinMedicine.com Animation Description: This patient-friendly animation describes the main role of insulin in the human body. When food is ingested, it travels along the digestive tract where it is broken down into its component nutrients in order to be absorbed into the bloodstream. One such nutrient is glucose, a simple sugar. Glucose gets absorbed by the stomach and intestines and then enters the bloodstream. It travels through the circulation...
https://www.biyologlar.com/the-role-of-insulin-in-the-human-body -
Wisconsin scientists find genetic recipe to turn stem cells to blood
The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.
https://www.biyologlar.com/wisconsin-scientists-find-genetic-recipe-to-turn-stem-cells-to-blood -
Amniotic stem cells demonstrate healing potential
Rice University and Texas Children's Hospital scientists are using stem cells from amniotic fluid to promote the growth of robust, functional blood vessels in healing hydrogels.
https://www.biyologlar.com/amniotic-stem-cells-demonstrate-healing-potential -
In a role reversal, RNAs proofread themselves
Cold Spring Harbor, NY - Building a protein is a lot like a game of telephone: information is passed along from one messenger to another, creating the potential for errors every step of the way. There are separate, specialized enzymatic machines that proofread at each step, ensuring that the instructions encoded in our DNA are faithfully translated into proteins. Scientists at Cold Spring Harbor Laboratory (CSHL) have uncovered a new quality control mechanism along this path, but in a...
https://www.biyologlar.com/in-a-role-reversal-rnas-proofread-themselves -
Role of telomeres in plant stem cells discovered
The role played by telomeres in mammalian cells has been known for several years. It is also known that these non-coding DNA sequences, which are found at the ends of the chromosomes, protect them and are necessary to ensure correct cell division.
https://www.biyologlar.com/role-of-telomeres-in-plant-stem-cells-discovered -
Kanser Tedavisinde Yeni Silahlar
İnsanlık, bildiğimiz kadarı ile, yazılı tarih boyunca kendi tarihi kadar eski ve bir o kadar da ürkütücü kanserle mücadele etmiş ve hala bu mücadelesine devam etmekte. M.Ö. 3000 yıllarında yazıldığı tahmin edilen eski Mısır metinlerinde meme ülserlerinin (o zaman henüz kanser kelimesi literatürde yoktu) koterle yakılarak alındığı anlatılıyor. Günümüzde ise kanser hastaları radyoterapi, kemoterapi ve cerrahi müdahaleler ile tedavi edilmeye çalışılmakta....
https://www.biyologlar.com/kanser-tedavisinde-yeni-silahlar