A new genome editing method brings the possibility of gene therapies closer to reality
Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy.
Stem Cell Research
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In some genetic cases of microcephaly, stem cells fail to launch
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Embryonic gene Nanog reverses aging in adult stem cells
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Gene controls regeneration of injured muscle by adult stem cells
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Breakthrough in scaling up life-changing stem cell production
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New procedure allows long-term culturing of adult stem cells
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Stem cell transplant from young to old can heal stomach ulcers
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Scientists discover oldest plant root stem cells
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Penn bioengineers show why lab-made stem cells might fail: Errors in DNA folding
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Stem cell therapy improves outcomes in severe heart failure
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A quartet of genes controls growth of blood stem cells
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New way to harvest stem cells better for donors
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Oncogene controls stem cells in early embryonic development
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Hacking the programs of cancer stem cells
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Combining adult stem cells with hormone may speed bone fracture healing
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Discovery of an embryonic switch for cancer stem cell generation