Toplam 183 içerik listeleniyor
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Gene therapy treats all muscles in the body in muscular dystrophy dogs
Muscular dystrophy, which affects approximately 250,000 people in the U.S., occurs when damaged muscle tissue is replaced with fibrous, fatty or bony tissue and loses function. For years, scientists have searched for a way to successfully treat the most common form of the disease, Duchenne Muscular Dystrophy (DMD), which primarily affects boys. Now, a team of University of Missouri researchers have successfully treated dogs with DMD and say that human clinical trials are being planned in the...
https://www.biyologlar.com/gene-therapy-treats-all-muscles-in-the-body-in-muscular-dystrophy-dogs-haber-8760 -
Meme kanseri bakteriyel dengesizliklerle bağlantılı
Çalışma, sağlıklı ve kanserli göğüs dokusunda bakteriyel kompozisyonunun karşılaştırılmasını içermektedir. Credit: © Ivan / Fotolia
https://www.biyologlar.com/meme-kanseri-bakteriyel-dengesizliklerle-baglantili -
Meme kanseri bakteriyel dengesizliklerle bağlantılı
Çalışma, sağlıklı ve kanserli göğüs dokusunda bakteriyel kompozisyonunun karşılaştırılmasını içermektedir. Credit: © Ivan / Fotolia
https://www.biyologlar.com/meme-kanseri-bakteriyel-dengesizliklerle-baglantili -
Tedavide ‘’Kök Hücre’’
Vücudumuzda yaşlanan ve ölen hücrelerin yerlerine yenileri oluşturulmaktadır. Bununla birlikte, yabancı antijenlerle savaşmak için vücut özel savunma hücreleri de üretmektedir. Gözümüzdeki hücreler görme, pankreastaki hücreler salgı, akciğerdeki hücreler solunum için farklılaşmaktadır.
https://www.biyologlar.com/tedavide-kok-hucre -
Tedavide ‘’Kök Hücre’’
Vücudumuzda yaşlanan ve ölen hücrelerin yerlerine yenileri oluşturulmaktadır. Bununla birlikte, yabancı antijenlerle savaşmak için vücut özel savunma hücreleri de üretmektedir. Gözümüzdeki hücreler görme, pankreastaki hücreler salgı, akciğerdeki hücreler solunum için farklılaşmaktadır.
https://www.biyologlar.com/tedavide-kok-hucre -
KÖK HÜCRELERE BAKIŞ:TANIMLAR, KAVRAMLAR ve SINIFLANDIRMALAR
İki binli yıllarla beraber kök hücrelerin rejeneratif tıp (yenileyici tıp) alanındaki öneminin giderek arttığını ve tıbbın geleceğini şekillendirme potansiyelini gözlemlemekteyiz.
https://www.biyologlar.com/kok-hucrelere-bakistanimlar-kavramlar-ve-siniflandirmalar -
Stem-cell approach shows promise for Duchenne muscular dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD. Their findings appear in the journal Stem Cells Translational Medicine. Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without...
https://www.biyologlar.com/stem-cell-approach-shows-promise-for-duchenne-muscular-dystrophy -
Blocking cells' movement to stop the spread of cancer
Insights into how cells move through the body could lead to innovative techniques to stop cancer cells from spreading and causing secondary tumours, according to new UCL research. Scientists discovered that cells can change into an invasive, liquid-like state to readily navigate the narrow channels in our body. This transformation is triggered by chemical signals, which could be blocked in order to stop cancer cells from spreading. Most cancer deaths are not due to primary tumours, but to...
https://www.biyologlar.com/blocking-cells-movement-to-stop-the-spread-of-cancer -
Stem-cell-based strategy boosts immune system in mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. The researchers showed that, in mice, the tissue can be used to foster the development of white blood cells the body needs to mount healthy immune responses and to prevent harmful autoimmune reactions. The scientists who developed the thymus cells — which caused the proliferation and maturation of functioning immune cells...
https://www.biyologlar.com/stem-cell-based-strategy-boosts-immune-system-in-mice -
Stem cell breakthrough could set up future transplant therapies
A new method for creating stem cells for the human liver and pancreas, which could enable both cell types to be grown in sufficient quantities for clinical use, has been developed by scientists. Using the technique, researchers have for the first time been able to grow a pure, self-renewing population of stem cells specific to the human foregut, the upper section of the human digestive system. These so-called "Foregut stem cells" could then be developed further to produce liver or pancreatic...
https://www.biyologlar.com/stem-cell-breakthrough-could-set-up-future-transplant-therapies -
New stem cells go back further
One of the obstacles to employing human embryonic stem cells for medical use lies in their very promise: They are born to rapidly differentiate into other cell types.
https://www.biyologlar.com/new-stem-cells-go-back-further -
Enzyme controlling metastasis of breast cancer identified
Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide. An estimated 40,000 women in America will die of breast cancer in 2014, according to the American Cancer Society. "The take-home message of the study is that we have found a way to target breast cancer metastasis through a pathway...
https://www.biyologlar.com/enzyme-controlling-metastasis-of-breast-cancer-identified -
Scientists discover an on-off switch for aging cells
Scientists at the Salk Institute have discovered an on-and-off "switch" in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age. In our bodies, newly divided cells constantly replenish lungs, skin, liver and other organs. However, most human cells cannot divide indefinitely–with each division, a cellular timekeeper at the ends of chromosomes shortens. When...
https://www.biyologlar.com/scientists-discover-an-on-off-switch-for-aging-cells -
Researchers use human stem cells to create light-sensitive retina in a dish
Using a type of human stem cell, Johns Hopkins researchers say they have created a three-dimensional complement of human retinal tissue in the laboratory, which notably includes functioning photoreceptor cells capable of responding to light, the first step in the process of converting it into visual images.
https://www.biyologlar.com/researchers-use-human-stem-cells-to-create-light-sensitive-retina-in-a-dish -
The Role of Insulin in the Human Body
Developed and produced by http://www.MechanismsinMedicine.com Animation Description: This patient-friendly animation describes the main role of insulin in the human body. When food is ingested, it travels along the digestive tract where it is broken down into its component nutrients in order to be absorbed into the bloodstream. One such nutrient is glucose, a simple sugar. Glucose gets absorbed by the stomach and intestines and then enters the bloodstream. It travels through the circulation...
https://www.biyologlar.com/the-role-of-insulin-in-the-human-body -
Snake venom helps hydrogels stop the bleeding
A nanofiber hydrogel infused with snake venom may be the best material to stop bleeding quickly, according to Rice University scientists. The hydrogel called SB50 incorporates batroxobin, a venom produced by two species of South American pit viper. It can be injected as a liquid and quickly turns into a gel that conforms to the site of a wound, keeping it closed, and promotes clotting within seconds. Rice chemist Jeffrey Hartgerink, lead author Vivek Kumar and their colleagues reported their...
https://www.biyologlar.com/snake-venom-helps-hydrogels-stop-the-bleeding -
Amniotic stem cells demonstrate healing potential
Rice University and Texas Children's Hospital scientists are using stem cells from amniotic fluid to promote the growth of robust, functional blood vessels in healing hydrogels.
https://www.biyologlar.com/amniotic-stem-cells-demonstrate-healing-potential -
Role of telomeres in plant stem cells discovered
The role played by telomeres in mammalian cells has been known for several years. It is also known that these non-coding DNA sequences, which are found at the ends of the chromosomes, protect them and are necessary to ensure correct cell division.
https://www.biyologlar.com/role-of-telomeres-in-plant-stem-cells-discovered -
Epigenetic signatures that differentiate triple-negative breast cancers
The new study, published in Nature Communications, compares the breast cancer DNA 'methylome' with that of healthy individuals. The methylome provides a new picture of the genome and shows how it is epigenetically 'decorated' with methyl groups, a process known as DNA 'methylation'.
https://www.biyologlar.com/epigenetic-signatures-that-differentiate-triple-negative-breast-cancers -
Stem cells might heal damaged lungs
Collectively, such diseases of the airways as emphysema, bronchitis, asthma and cystic fibrosis are the second leading cause of death worldwide.
https://www.biyologlar.com/stem-cells-might-heal-damaged-lungs -
New brain mapping reveals unknown cell types
Using a process known as single cell sequencing, scientists at Karolinska Institutet have produced a detailed map of cortical cell types and the genes active within them. The study, which is published in the journal 'Science', marks the first time this method of analysis has been used on such a large scale on such complex tissue. The team studied over three thousand cells, one at a time, and even managed to identify a number of hitherto unknown types. "If you compare the brain to a fruit...
https://www.biyologlar.com/new-brain-mapping-reveals-unknown-cell-types -
Restoring vision with stem cells
Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital. ARMD is a common eye problem caused by the loss of cones. Bernier's team has developed a highly effective in vitro technique for producing light sensitive retina cells from human embryonic stem cells. "Our...
https://www.biyologlar.com/restoring-vision-with-stem-cells -
Neurons constantly rewrite their DNA
Johns Hopkins scientists have discovered that neurons are risk takers: They use minor "DNA surgeries" to toggle their activity levels all day, every day. Since these activity levels are important in learning, memory and brain disorders, the researchers think their finding will shed light on a range of important questions. A summary of the study will be published online in the journal Nature Neuroscience on April 27. "We used to think that once a cell reaches full maturation, its DNA is totally...
https://www.biyologlar.com/neurons-constantly-rewrite-their-dna -
Great Barrier Reef marine reserves combat coral disease
A new and significant role for marine reserves on the Great Barrier Reef has been revealed, with researchers finding the reserves reduce the prevalence of coral diseases. It's been known for some time that marine reserves are important for maintaining and enhancing fish stocks, but this is the first time marine reserves have been shown to enhance coral health on the Great Barrier Reef. Researchers from the ARC Centre of Excellence for Coral Reef Studies at James Cook University found that...
https://www.biyologlar.com/great-barrier-reef-marine-reserves-combat-coral-disease -
Novel stem cell line avoids risk of introducing transplanted tumors
Human pluripotent stem cells (hPSC) can become any type of cell in the adult body, offering great potential in disease modeling, drug discovery and creating replacement cells for conditions ranging from cardiovascular to Alzheimer's disease. But that promise comes with a risk: the possibility that transplanted hPSCs might also develop as unwanted tumors. In a new study published November 10, 2015 in the online journal eLIFE, researchers at University of California, San Diego School of Medicine...
https://www.biyologlar.com/novel-stem-cell-line-avoids-risk-of-introducing-transplanted-tumors -
Proteomics identifies DNA repair toolbox
During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication machinery gets stuck?
https://www.biyologlar.com/proteomics-identifies-dna-repair-toolbox -
Odd histone helps suppress jumping genes in stem cells, study says
A family of proteins known as histones provides support and structure to DNA, but for years, scientists have been puzzling over occasional outliers among these histones, which appear to exist for specific, but often mysterious reasons. Now, researchers have uncovered a new purpose for one such histone variant: preventing genetic mutations by keeping certain so-called "jumping genes" in place. This research, which began at Rockefeller University and was published May 4 in Nature, reveals a...
https://www.biyologlar.com/odd-histone-helps-suppress-jumping-genes-in-stem-cells-study-says -
New GTEx findings show how DNA differences influence gene activity, disease susceptibility
Researchers funded by the National Institutes of Health Genotype-Tissue Expression (GTEx) project have created a new and much-anticipated data resource to help establish how differences in an individual's genomic make-up can affect gene activity and contribute to disease. The new resource will enable scientists to examine the underlying genomics of many different human tissues and cells at the same time, and promises to open new avenues to the study and understanding of human biology. GTEx...
https://www.biyologlar.com/new-gtex-findings-show-how-dna-differences-influence-gene-activity-disease-susceptibility -
Hacking the programs of cancer stem cells
All tumor cells are the offspring of a single, aberrant cell, but they are not all alike. Only a few retain the capacity of the original cell to create an entire tumor.
https://www.biyologlar.com/hacking-the-programs-of-cancer-stem-cells -
Herpes outbreak, other marine viruses linked to coral bleaching event
A study at Oregon State University has concluded that significant outbreaks of viruses may be associated with coral bleaching events, especially as a result of multiple environmental stresses. One such event was documented even as it happened in a three-day period. It showed how an explosion of three viral groups, including a herpes-like virus, occurred just as corals were bleaching in one part of the Great Barrier Reef off the east coast of Australia. The findings, reported in Frontiers in...
https://www.biyologlar.com/herpes-outbreak-other-marine-viruses-linked-to-coral-bleaching-event -
Researchers build molecule that could significantly reduce brain damage in stroke victims
Research teams separated by 14 hours and 9,000 miles have collaborated to advance prospective treatment for the world's second-leading cause of death. University of Nebraska-Lincoln chemists partnered with medical researchers from the National University of Singapore to develop a molecule that can inhibit an enzyme linked with the onset of stroke. Most strokes occur when a disruption of blood flow prevents oxygen and glucose from reaching brain tissue, ultimately killing neurons and other...
https://www.biyologlar.com/researchers-build-molecule-that-could-significantly-reduce-brain-damage-in-stroke-victims -
Griffith uses 3-D tissue engineering to revolutionize dental disease
The discomfort and stigma of loose or missing teeth could be a thing of the past as Griffith University researchers pioneer the use of 3D bioprinting to replace missing teeth and bone. The three-year study, which has been granted a National Health and Medical Research Council Grant of $650,000, is being undertaken by periodontist Professor Saso Ivanovski from Griffith's Menzies Health Institute Queensland. As part of an Australian first, Professor Ivanovski and his team are using the latest...
https://www.biyologlar.com/griffith-uses-3-d-tissue-engineering-to-revolutionize-dental-disease -
Algae use their 'tails' to gallop and trot like quadrupeds
Long before there were fish swimming in the oceans, tiny microorganisms were using long slender appendages called cilia and flagella to navigate their watery habitats.
https://www.biyologlar.com/algae-use-their-tails-to-gallop-and-trot-like-quadrupeds -
These gigantic whales have nerves like bungee cords
Nerves aren't known for being stretchy. In fact, "nerve stretch injury" is a common form of trauma in humans. But researchers reporting in
https://www.biyologlar.com/these-gigantic-whales-have-nerves-like-bungee-cords -
Penn bioengineers show why lab-made stem cells might fail: Errors in DNA folding
Induced pluripotent stem cells hold promise for regenerative medicine because they can, in theory, turn into any type of tissue and because they are made from a patient's own adult cells, guaranteeing compatibility. However, the technique that turns adult cells into these iPS cells is not foolproof; after reverting to their pluripotent state, these cells don't always correctly differentiate back into adult cells. Researchers from the University of Pennsylvania have now discovered one of the...
https://www.biyologlar.com/penn-bioengineers-show-why-lab-made-stem-cells-might-fail-errors-in-dna-folding -
A microtubule 'roadway' in the retina helps provide energy for vision
Researchers have discovered a thick band of microtubules in certain neurons in the retina that they believe acts as a transport road for mitochondria that help provide energy required for visual processing. The findings appear in the July issue of The Journal of General Physiology. The retina is a layer of tissue in the back of the eye that converts light into nerve impulses. The retina contains small, specialized neurons called bipolar cells that transmit information from light-sensitive...
https://www.biyologlar.com/a-microtubule-roadway-in-the-retina-helps-provide-energy-for-vision -
Clues contained in ancient brain point to the origin of heads in early animals
A new study from the University of Cambridge has identified one of the oldest fossil brains ever discovered - more than 500 million years old - and used it to help determine how heads first evolved in early animals. The results, published today (7 May) in the journal Current Biology, identify a key point in the evolutionary transition from soft to hard bodies in early ancestors of arthropods, the group that contains modern insects, crustaceans and spiders. The study looked at two types of...
https://www.biyologlar.com/clues-contained-in-ancient-brain-point-to-the-origin-of-heads-in-early-animals -
DNA damage by ultrashort pulses of intense laser light
DNA damage caused by very low-energy electrons and OH-radicals formed upon irradiation of water by ultrashort pulses of very intense laser light.
https://www.biyologlar.com/dna-damage-by-ultrashort-pulses-of-intense-laser-light -
DNA damage by ultrashort pulses of intense laser light
DNA damage caused by very low-energy electrons and OH-radicals formed upon irradiation of water by ultrashort pulses of very intense laser light.
https://www.biyologlar.com/dna-damage-by-ultrashort-pulses-of-intense-laser-light -
New procedure allows long-term culturing of adult stem cells
A new procedure developed at Massachusetts General Hospital (MGH) may revolutionize the culturing of adult stem cells. In their report that has been published online prior to its appearance in the August 6 issue of Cell Stem Cell, the team describes generating and expanding airway stem cells from the sorts of tissue samples collected during routine treatment of lung disorders. The overall approach appears applicable to several other tissue types, including skin and the linings of the...
https://www.biyologlar.com/new-procedure-allows-long-term-culturing-of-adult-stem-cells -
Watching the luminescent gene switch
The system consists of two newly developed programs that automatically identify the 3-D positions of target areas based on the signals from the scintillators (shown as white dots), and determine...
https://www.biyologlar.com/watching-the-luminescent-gene-switch -
Watching the luminescent gene switch
The system consists of two newly developed programs that automatically identify the 3-D positions of target areas based on the signals from the scintillators (shown as white dots), and determine...
https://www.biyologlar.com/watching-the-luminescent-gene-switch -
KUDUZ VİRÜSÜ
Rhabdovirus’larin en önemli üyesidir. Lipoprotein zarf ile sarılmış mermi şeklinde kapsid içinde tek iplikli RNA içerir. Virion RNA'ya bağımlı RNA polimeraz içerir. Kuduz virüsünün geniş bir konak grubu vardır. Kuduz virüsü hücre yüzeyindeki asetilkolin reseptörüne bağlanır. Virüs kuduz bir hayvanın ısırması ile bulaşır. Bulaştırıcı hayvanlarda viral ensefalite bağlı anormal davranışlar gözlenirken, yarasalarda normal bir görüntü sergiler...
https://www.biyologlar.com/kuduz-virusu -
Breakthrough in scaling up life-changing stem cell production
Scientists have discovered a new method of creating human stem cells which could solve the big problem of the large-scale production needed to fully realise the potential of these remarkable cells for understanding and treating disease.
https://www.biyologlar.com/breakthrough-in-scaling-up-life-changing-stem-cell-production -
Gene fuels age-related obesity and diabetes
Practically everyone gets fatter as they get older, but some people can blame their genes for the extra padding. Researchers have shown that two different mutations in a gene called ankyrin-B cause cells to suck up glucose faster than normal, fattening them up and eventually triggering the type of diabetes linked to obesity. The more severe of the two mutations, called R1788W, is carried by nearly one million Americans. The milder mutation, known as L1622I, is shared by seven percent of the...
https://www.biyologlar.com/gene-fuels-age-related-obesity-and-diabetes -
Gene controls regeneration of injured muscle by adult stem cells
A key gene enables the repair of injured muscle throughout life. This is the finding of a study in mice led by researchers at NYU Langone Medical Center and the University of Colorado at Boulder, and published online July 21 in Cell Reports.
https://www.biyologlar.com/gene-controls-regeneration-of-injured-muscle-by-adult-stem-cells -
Embryonic gene Nanog reverses aging in adult stem cells
The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
https://www.biyologlar.com/embryonic-gene-nanog-reverses-aging-in-adult-stem-cells -
Embryonic gene Nanog reverses aging in adult stem cells
The images above show, from left to right, functioning stem cells, stem cells no longer functioning due to Hutchinson-Gilford Progeria syndrome (HGPS), and stem cells previously not functioning
https://www.biyologlar.com/embryonic-gene-nanog-reverses-aging-in-adult-stem-cells -
Quantum dots with impermeable shell: A powerful tool for nanoengineering
Images of ZnO quantum dots prepared by the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw, taken by transmission electron microscopy. False colors.
https://www.biyologlar.com/quantum-dots-with-impermeable-shell-a-powerful-tool-for-nanoengineering